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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 9: Human Diseases and Autophagosome

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by Hayat MA
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 9: Human Diseases and Autophagosome by Hayat MA

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to both cellular processes while helping researchers to explore their potentially important connections.

Volume 9 emphasizes the role of autophagy in diseases, such as leukemia, antifungal and antibacterial immunity, and transplantation. This volume also explains in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of omegasomes to autophagosomes. This information is important because one of the major functions of autophagy is to degrade and eliminate excessive, old, and harmful materials from the cell. Autophagosomes receive these materials (cellular cargo) and transport them to lysosomes for degradation. Lysosomes contain the digestive enzymes (hydrolases) that breakdown proteins, lipids, carbohydrates, etc. (self-digestion). To further explain this phenomenon, the role of endoplasmic reticulum (ER) in the formation of autophagosomes is discussed. ULK1 and Beclin 1 proteins are also important in the initial formation of autophagosomes, which are discussed. Because much of the early research in this area was carried out using yeast cells, the role of Golgi complex in the autophagosome formation in these cells is explained.

Volume 9 also includes an explanation of the role of autophagy-related gene ATG5 in cancer (e.g., gastrointestinal cancer). Paradoxically, autophagy is a "double-edged sword,? because it eliminates some pathogens, whereas it can be used by some intracellular pathogens to multiply and cause infection. This book is an asset to newcomers as a concise overview of the role of autophagy in necrosis and inflammation, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge.

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Ebook Details
Pages: 430
Size: 12.3 MB
Publisher: Academic Press
Date published:   2016
ISBN: 2370007459377 (DRM-EPUB)
9780128029510 (DRM-PDF)

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This product is listed in the following categories:

Nonfiction > Medical > Immunology
Nonfiction > Science > Life Sciences > Biology > Microbiology

This author has products in the following categories:

Nonfiction > Medical > Oncology
Nonfiction > Science > Microscopes & Microscopy
Nonfiction > Medical > Biochemistry
Nonfiction > Medical > Histology
Nonfiction > Medical > Pathology
Nonfiction > Medical > Immunology
Nonfiction > Science > Life Sciences > Biology > Microbiology
Nonfiction > Science > Life Sciences > Biology
Nonfiction > Science > Biotechnology
Nonfiction > Science > Life Sciences > Biology > Molecular Biology
Nonfiction > Science > Chemistry
Nonfiction > Medical > Neuroscience
Nonfiction > Nature > Wildlife
Nonfiction > Medical > Neurology

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